Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells
Summary: How chromosome organization is related to genome function remains poorly understood.Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to hus726040als214 create topologically associating domains (TADs) to regulate gene expression.Here, we examine chromosome conformation in embryonic stem cells lacking cohesin and f